"Low glutathione has been linked to abnormalities in the lung."

Several lung disorders are believed to be characterized by an increase of oxidant burden in the tiny air sacs in the lungs, potentially depleting lung glutathione. Low glutathione has been linked to abnormalities in the lung. There is now sufficient data to strongly implicate free radical injury in the start and maintenance of several lung disorders in humans.

SOURCE: Morris PE, Bernard GR. Significance of glutathione in lung disease and implication for therapy. Am J Med Sci. 1994 Feb;307(2):119-27

"Glutathione plays a major role in pulmonary antioxidant protection."

Oxidant/antioxidant imbalance can occur in obstructive airways disease as a result of ongoing inflammation. Glutathione (GSH) plays a major role in pulmonary antioxidant protection.
As an alternative or complement to anti-inflammatory therapy, augmenting antioxidant protection could diminish the effects of inflammation.

We describe a case of a patient who had obstructive lung disease responsive to corticosteroids, and low whole blood GSH levels. After 1 month of supplementation with an oral supplement designed to provide GSH precursors, whole blood GSH levels and pulmonary function increased significantly and dramatically.

SOURCE: Bryce Lothian, Vijaylaxmi Gre, et al. Treatment of Obstructive Airway Disease with a Cysteine Donor Protein Supplement. Chest. 2000 Jan; 17: 914-16

"The evidence is overwhelming that glutathione plays a vital role..."

GSH is an important protective antioxidant against free radicals and other oxidants. GSH has been shown to be critical to the lungs' antioxidant defenses particularly in protecting airspace from oxidative free radical injury and inflammation. The evidence is overwhelming that glutathione plays a vital role in cellular modulation of the inflammatory response, antioxidant capability.

SOURCE: I. Rahman, W. MacNee. European Respiratory Journals. 2000; 16:534-54

"High GSH levels are important and as such compromised GSH levels may be detrimental."

SOURCE: Kelly FJ. Food and Chemical Toxicology. Glutathione: In Defense of the Lung. Sept: 1999 37(9-10): 963-6

"Glutathione, an important antioxidant in the lung, plays a crucial role in protecting epithelial cells from injury and inflammation."

Existence of an increased oxidative stress has been confirmed in patients with acute exacerbation of COPD. This study aims to examine the extent and time-course of antioxidant defense in patients with an acute exacerbation of COPD in comparison with stable patients.

SOURCE: Sadowska, Anna, Chris Luyten, et. al. Systemic Antioxidant Defenses during Acute Exacerbation of Chronic Obstructive Pulmonary Disease. Respirology. Nov 2006; 11 (6):741-47

"Glutathione plays an important role in the protection of the CF lung against oxidant induced lung injury."

Chronic progressive lung disease is the most serious complication of cystic fibrosis (CF). Glutathione plays an important role in the protection of the CF lung against oxidant induced lung injury. Glutathione (GSH) is a ubiquitous tripeptide that plays a crucial role in the protection of the lung from oxidant-induced lung damage. Patients with CF have low levels of GSH in the epithelial lining fluid , suggesting that deficiency in GSH may influence the development of CF lung disease."

SOURCE: American Journal of Respiratory and Critical Care Medicine, Aug 15,2006 by McKone, Edward , Et al

"There is good evidence to suggest that the lack of glutathione in lung fluid plays a key role in the chronic inflammation and infection that occurs."

The secretion of a peptide called glutathione by lung cells is impaired in cystic fibrosis, and there is good evidence to suggest that the lack of glutathione in lung fluid plays a key role in the chronic inflammation and infection that occurs.

SOURCE: Chest, January 2005

"Glutathione functions as a major frontline defense against the build-up of oxidants in the lung."

The lung disease of cystic fibrosis is associated with a chronic inflammatory reaction and an over abundance of oxidants relative to antioxidants. Glutathione functions as a major frontline defense against the build-up of oxidants in the lung."

SOURCE: J Cystic Fibrosis. 2003 Dec;2(4):195

"Glutathione..is vital...protective antioxidant in the lungs."

Glutathione (GSH), a ubiquitous tripeptide thiol, is a vital intra- and extracellular protective antioxidant in the lungs. "

SOURCE: Lung glutathione and oxidative stress: implications in cigarette smoke-induced airway disease

"Glutathione is one of the most important antioxidants in human lungs and lung secretions."

The major contribution to oxidant related lung damage in COPD is from the oxidant/antioxidant imbalance and possibly impaired antioxidant defence. Glutathione (GSH) is one of the most important antioxidants in human lung and lung secretions.

SOURCE: Department of Respiratory Medicine, Medical School, University of Edinburgh

"Lung diseases...correlates with the decrease in glutathione."

In various lung diseases, the severity of the disease state correlates with the decrease in glutathione on the surface of pulmonary epithelial cells.

SOURCE: Lung, Vol. 169, pp. 123-138, 1991